• Association of vitamin D status with arterial blood pressure and hypertension risk: A mendelian randomisation study 

      Vimaleswaran, Kerani S.; Cavadino, Alana; Berry, Diane J.; Jorde, Rolf; Grimnes, Guri; Dieffenbach, Aida Karina; Lu, Chen; Alves, Alexessander Couto; Heerspink, Hiddo J. Lambers; Tikkanen, Emmi; Eriksson, Joel; Wong, Andrew; Mangino, Massimo; Jablonski, Kathleen A.; Nolte, Ilja M.; Houston, Denise K.; Ahluwalia, Tarunveer Singh; van der Most, Peter J.; Pasko, Dorota; Zgaga, Lina; Thiering, Elisabeth; Schöttker, B; Saum, KU; Brenner, H; Järvelin, MR; Tzoulaki, I; Snieder, H; Stolk, RP; Hartman, CA; de Boer, RA; van der Harst, P; Navis, G; de Borst, MH; Lorentzon, M; Mellström, D; Ohlsson, C; Hardy, R; Kuh, D; Cooper, JA; Acharya, J; Humphries, SE; Hingorani, AD; Kumari, M; Kivimaki, M; Spector, TD; Kritchevsky, SB; Lohman, KK; Sørensen, TIA; Frayling, TM; Campbell, H; Theodoratou, E; Fraser, RM; Wilson, JF; Rudan, I; Price, JF; McLachlan, S; Vitart, V; Navarro, P; Huffman, JE; Hayward, C; Wright, AF; Tiesler, CMT; Heinrich, J; McCarthy, MI; Ingelsson, E; Arden, N; Cooper, C; Dupuis, J; Herzig, KH; Sebert, S; Pouta, A; Laitinen, J; Kleber, ME; März, W; Jameson, K; Osmond, C; Raitakari, O; Ripatti, S; Lahti, J; Eriksson, JG; Penninx, BW; Billings, LK; Florez, JC; Rejnmark, L; Langdahl, BL; Paternoster, L; Hernandez, DG; Byberg, L; Michaelsson, K; Hagström, E; Melhus, H; Ljunggren, O; Lind, L; Jula, A; Polasek, O; Salomaa, V; Karlsson, M; Bandinelli, S; Lehtimäki, T; Wang, TJ; Pilz, S; Whittaker, JC (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-06-25)
      Background Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk.<p> <p>Methods In this mendelian randomisation study, we generated ...
    • The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study 

      Winkler, Thomas W; Justice, Anne E; Graff, Mariaelisa; Barata, Llilda; Feitosa, Mary F.; Chu, Su; Czajkowski, Jacek; Esko, Tõnu; Fall, Tove; Kilpeläinen, Tuomas O.; Lu, Yingchang; Mägi, Reedik; Mihailov, Evelin; Pers, Tune H.; Rüeger, Sina; Teumer, Alexander; Ehret, Georg B.; Ferreira, Teresa; Heard-Costa, Nancy L.; Karjalainen, Juha; Lagou, Vasiliki; Mahajan, Anubha; Neinast, Michael D.; Prokopenko, Inga; Simino, Jeannette; Teslovich, Tanya M.; Jansen, Rick; Westra, Harm-Jan; White, Charles C.; Absher, Devin; Ahluwalia, Tarunveer S.; Ahmad, Shafqat; Albrecht, Eva; Alves, Alexessander Couto; Bragg-Gresham, Jennifer L.; de Craen, Anton J. M.; Bis, Joshua C.; Bonnefond, Amélie; Cadby, Gemma; Cheng, Yu-Ching; Chiang, Charleston W. K.; Delgado, Graciela; Demirkan, Ayse; Dueker, Nicole; Eklund, Niina; Eiriksdottir, Gudny; Holmen, Oddgeir; Hveem, Kristian; Njølstad, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-01)
      Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants ...